脑转移患者预后差,目前没有很好的治疗方案,而尼拉帕利组织分布好,透膜性能高,临床前研究显示其在脑组织中显示出良好的抑瘤效果,那么在实际临床中,尼拉帕利能否对合并脑转移的肿瘤患者有效呢?
本期OC文献精读特别邀请到了蚌埠医学院第一附属医院的李玉芝教授,解读2019-2022年发布的5篇尼拉帕利脑转移的个案报告。
01 背景介绍
参考文献:
1.Gray S, Khor XY,Yiannakis D. BMJ Case Rep 2019;12:e230738. doi:10.1136/bcr-2019-230738
2.Comprehensive genomic profiling-guided niraparib treatment of metastatic triple-negative breast cancer patient with extensive brain metastasis: a case report and review of the literature. J Immunother Precis Oncol. 2021; 4:16–20. DOI: 10.36401/JIPO-20-24.
3.Tao Mengyu,Cheng Jiejun,Wu Xia,BRCA2Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic -mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review.[J] .Onco Targets Ther, 2020, 13: 12979-12986.
4.Wang Qing,Zhang Fenghua,Gao Hongyan et al. Successful treatment of a patient with brain metastases from endometrial cancer using Niraparib: a case report.[J] .Ann Palliat Med, 2021, 10: 818-827.
5.Zhang Zhenhua,Xu Muying,Sakandar Abbas et al. Successful Treatment of a Patient With Brain Metastasis From Ovarian Cancer With BRCA Wild Type Using Niraparib: A Case Report and Review of the Literature.[J] .Front Oncol, 2022, 12: 873198.
扫二维码
关注OC资讯
OC资讯小助手
为您提供更多帮助